TABLE 5.
Viral loads, symptom scores, and respiration rates in bRSV-infected cattle treated with QD GS1 or placebo (study 2)
| Parameter (units) | Mean (SD) for group treated witha: |
P valuec | ||
|---|---|---|---|---|
| GS1 |
Vehicle (n = 4) | |||
| Early (n = 3)b | Delayed (n = 6) | |||
| AUC of log10 viral load (log10 genome equivalents · day/ml) | 8.6 (8.0) | 18.8 (8.1) | 21.6 (12.3) | 0.33 |
| AUC of symptom score (score · day) | 657.7 (182.6) | 606.4 (297.3) | 1,150.8 (643.7) | 0.18 |
| AUC of respiration rate (no. of breaths · day/min) | 221.0 (17.1) | 262.7 (60.6) | 319.5 (110.4) | 0.22 |
a
The GS1 groups were treated early (24 h postinoculation [h.p.i.]) or later (delayed) (72 h.p.i.) The median values were similar to the mean values.
b
One animal (group 1, calf 1-3 [calf 3 from group 1]) was removed from analysis due to secondary infection.
c
Rank ANCOVA testing the null hypothesis of no difference between any treatment.