FIG 5.

Heteroresistant cells are more resistant to oxidative burst. Shown are the amounts of reactive oxygen species (ROS) (A), lipid peroxidation (TBARs) (B), and total SOD (C) and PER (D) activities after 1 h of treatment with itraconazole. Results are expressed as the ratio of the treatment to the control. Statistical differences between the original cells and their heteroresistant clones are represented by the horizontal line (P < 0.05). Differences between L135/03 and L127/01 original cells are represented by one asterisk (P < 0.05) and those between L135/03 and L127/01 heteroresistant clones by two asterisks (P < 0.05). Data represent the means ± SE from two independent experiments consisting of triplicate assays. O, original; H, heteroresistant.