TABLE 1.
Identification of bacteria from pus culture and MICs of antibiotic agentsa
| Agent | MIC (μg/ml) for: |
||
|---|---|---|---|
| E. coli with NDM-1 and ESBL | C. freundii with NDM-1 and ESBL | K. pneumoniae with ESBL | |
| CTX | >32 | >32 | >32 |
| CAZ | >16 | >16 | <8 |
| CFPM | >16 | >16 | >16 |
| AZT | >16 | >16 | 8 |
| IPM-CS | >8 | >8 | <1 |
| MEPM | >8 | 2 | <1 |
| LVFX | >4 | <0.5 | 2 |
| AMK | >32 | >32 | <4 |
| RFP | >4 | >4 | >4 |
| COL | 3.0 | 3.0 | <1 |
| COL + RFP | 1.0b | 1.0b | |
| COL + RFP + IPM | 1.5b | 1.0b | |
| COL + RFP + LVFX | 1.5b | 0.064b | |
| COL + TGC + RFP | 0.75b | 0.38b | |
| COL + TGC + IPM | 1.0b | 1.0b | |
| TGC | 0.75 | 0.75 | |
| TGC + COL | 1.0c | 0.75c | |
| TGC + RFP | 0.75c | 1.5c | |
| TGC + LVFX | 1.0c | 0.047c | |
| TGC + IPM | 1.0c | 0.5c | |
a
Abbreviations: AMK, amikacin; AZT, aztreonam; CAZ, ceftazidime; CFPM, cefepime; COL, colistin; CTX, cefotaxime; ESBL, extended-spectrum beta-lactamase; IPM-CS, imipenem-cilastatin; LVFX, levofloxacin; MEPM, meropenem; NDM-1, New Delhi metallo-beta-lactamase; TCG, tigecycline. In the Etest synergy test, breakpoint matching at each Etest strip replacement was as follows: LVFX (1 μg/ml), IPM-CS (1 μg/ml), COL (2 μg/ml), TGC (1 μg/ml), and RFP (4 μg/ml).
b
MIC of COL after preparation of other agents by the Etest.
c
MIC of TGC after preparation of other agents by the Etest.