TABLE 1.

Amino acids at position 289 of NA of virus recovered after treatment with NA inhibitors^a

Inoculum or sample	Treatment	Monkey	Amino acid at NA289
Inoculumb			R
Nasal swab	Saline solution	S1	R
	Saline solution	S2	R
	Saline solution	S3	R
	Oseltamivir	O2	R
	Oseltamivir	O3	K
	Peramivir	P1	K
	Peramivir	P3	R
Oral swab	Saline solution	S1	R
	Oseltamivir	O3	K
	Peramivir	P1	R
Tracheal swab	Saline solution	S3	R
	Peramivir	P1	K

^aNucleotide sequences determined by Sanger sequencing were translated to amino acids. Amino acid position 289 of NA was determined on the basis of an N9 neuraminidase of Anhui/1. R, arginine; K, lysine. All samples indicated in the table were collected 7 days after virus inoculation. Viral RNAs were extracted from swab samples in which virus was detected on day 7 as shown in Table S1 in the supplemental material. Samples without detection of virus on day 7 as shown in Table S1 were not examined.

^bViral genes were purified from the virus in the same stock lot as that used in inoculation of macaques on day 0.