TABLE 1.
Plasma concentration of ceftaroline and avibactam in volunteers receiving ceftaroline-avibactama
| Drug and visit day | Sampling time after start of administration (h) | Plasma concn (mg/liter) |
||||
|---|---|---|---|---|---|---|
| Mean | Median | Minimum | Maximum | SD | ||
| Ceftaroline | ||||||
| −1 | 0 | 0 | 0 | 0 | 0 | |
| 2 | 1 | 16.8 | 14.5 | 8.4 | 31.4 | 7.4 |
| 5 | 1 | 15.6 | 13.9 | 6.4 | 30.1 | 7.1 |
| 7 | 1 | 16.7 | 13.0 | 8.9 | 34.5 | 8.2 |
| 7 | 3 | 4.9 | 2.7 | 2.1 | 12.3 | 4.0 |
| 7 | 12 | 0.1 | 0.1 | 0 | 0.3 | 0.1 |
| Avibactam | ||||||
| −1 | 0 | 0 | 0 | 0 | 0 | |
| 2 | 1 | 21.3 | 14.2 | 5.9 | 61.6 | 16.8 |
| 5 | 1 | 20.8 | 11.2 | 5.5 | 55.8 | 18.6 |
| 7 | 1 | 20.3 | 10.6 | 0 | 59.2 | 21.0 |
| 7 | 3 | 2.3 | 1.0 | 0 | 8.2 | 2.7 |
| 7 | 12 | 0 | 0 | 0 | 0 | 0 |
a
Ceftaroline-avibactam administered as 600 mg ceftaroline fosamil and 600 mg avibactam i.v. over 1 h every 8 h on days 1 to 6 and a single dose on day 7.