TABLE 2.
Drug and visit day | Fecal concn (mg/kg) |
||||
---|---|---|---|---|---|
Mean | Median | Minimum | Maximum | SD | |
Ceftaroline | |||||
−1 | 0 | 0 | 0 | 0 | 0 |
2 | 1.7 | 0 | 0 | 18.4 | 4.9 |
5 | 2.9 | 0 | 0 | 35.4 | 9.5 |
7 | 0.3 | 0 | 0 | 1.4 | 0.5 |
9 | 0 | 0 | 0 | 0 | 0 |
14 | 0 | 0 | 0 | 0 | 0 |
21 | 0 | 0 | 0 | 0 | 0 |
Avibactam | |||||
−1 | 0 | 0 | 0 | 0 | 0 |
2 | 0.3 | 0 | 0 | 3.7 | 1.0 |
5 | 7.1 | 0 | 0 | 98.5 | 26.3 |
7 | 0.1 | 0 | 0 | 1.6 | 0.4 |
9 | 0 | 0 | 0 | 0 | 0 |
14 | 0 | 0 | 0 | 0 | 0 |
21 | 0 | 0 | 0 | 0 | 0 |
Ceftaroline-avibactam administered as 600 mg ceftaroline fosamil and 600 mg avibactam i.v. over 1 h every 8 h on days 1 to 6 and a single dose on day 7.