TABLE 1.
Demographic data of enrolled subjects
| Trait | Result by group |
||||
|---|---|---|---|---|---|
| Child-Pugh class Aa (n = 8) | Child-Pugh class Ba (n = 8) | Child-Pugh class Ca (n = 8) | Healthy control (n = 9) | Hepatically impaired total (n = 24) | |
| Sex (n [%]) | |||||
| Female | 3 (38) | 0 (0) | 3 (38) | 3 (33) | 6 (25) |
| Male | 5 (63) | 8 (100) | 5 (63) | 6 (67) | 18 (75) |
| Race (n [%]) | |||||
| Asian | 2 (25) | 0 (0) | 0 (0) | 0 (0) | 2 (8) |
| White | 6 (75) | 8 (100) | 8 (100) | 9 (100) | 22 (92) |
| Ethnicity (n [%]) | |||||
| Hispanic or Latino | 2 (25) | 5 (63) | 5 (63) | 5 (56) | 12 (50) |
| Not Hispanic or Latino | 6 (75) | 3 (38) | 3 (38) | 4 (44) | 12 (50) |
| Age (yr) | |||||
| Mean | 56.9 | 57.1 | 55.6 | 57.9 | 56.5 |
| Minimum | 49 | 49 | 42 | 51 | 42 |
| Maximum | 67 | 68 | 65 | 66 | 68 |
| Wt (kg) | |||||
| Mean | 77.1 | 89.2 | 85.0 | 77.4 | 83.8 |
| Minimum | 68.0 | 71.0 | 65.2 | 66.0 | 65.2 |
| Maximum | 106.9 | 115.3 | 110.5 | 89.6 | 115.3 |
| BMI, mean (kg/m2) | 27.1 | 29.5 | 31.2 | 27.3 | 29.3 |
a
Child-Pugh classes: A, mild hepatic impairment, mean score of 5.625; B, moderate impairment, mean score of 7.375; C, severe impairment, mean score of 10.625.