TABLE 3.
Liver-related chemistry changes from baseline, days 6 and 8
| Laboratory test | Day | Change from baseline (mean ± SD) in: |
|||
|---|---|---|---|---|---|
| Child-Pugh class A | Child-Pugh class B | Child-Pugh class C | Healthy control | ||
| ALT (IU/liter) | 6 | 6.4 ± 10.2 | 6.9 ± 8.9 | 2.5 ± 9.8 | 4.6 ± 6.2 |
| 8 | 4.0 ± 8.0 | 7.8 ± 6.9 | 6.3 ± 14.6 | 2.6 ± 4.5 | |
| AST (IU/liter) | 6 | 3.4 ± 7.9 | −1.5 ± 7.7 | 0.0 ± 26.5 | −0.4 ± 2.5 |
| 8 | 0.4 ± 5.9 | 0.1 ± 10.6 | 5.8 ± 22.4 | −0.6 ± 2.9 | |
| Direct bilirubin (mg/dl) | 6 | 0.06 ± 0.15 | 0.03 ± 0.05 | 0.11 ± 0.25 | 0.04 ± 0.09 |
| 8 | 0.00 ± 0.08 | 0.03 ± 0.05 | 0.04 ± 0.21 | 0.00 ± 0.05 | |
| Total bilirubin (mg/dl) | 6 | 0.00 ± 0.24 | 0.04 ± 0.29 | 0.14 ± 0.57 | 0.03 ± 0.20 |
| 8 | −0.13 ± 0.13 | −0.01 ± 0.25 | 0.00 ± 0.55 | −0.03 ± 0.17 | |