TABLE 2.

MICs of cephalosporin and carbapenem antibiotics against variants of PBP2 in isogenic strains of N. gonorrhoeae

PBP2 variant	MIC (mg/liter)a
	Cefixime	Ceftriaxone	Ertapenem	Meropenem
Wild type	0.0023 ± 0.0015	0.0005 ± 0	0.016 ± 0	0.016 ± 0
Nonmosaic I	0.008 ± 0	0.004 ± 0	0.0267 ± 0.0092	0.016 ± 0
Nonmosaic I H168Y	0.0053 ± 0.0023	0.0033 ± 0.0012	0.0267 ± 0.0092	0.016 ± 0
Nonmosaic II	0.0067 ± 0.0023	0.0033 ± 0.0012	0.0267 ± 0.0092	0.016 ± 0
Nonmosaic II A501V	0.0213 ± 0.0092	0.008 ± 0	0.0267 ± 0.0092	0.016 ± 0
Nonmosaic II V78I	0.0067 ± 0.0023	0.004 ± 0	0.0267 ± 0.0092	0.016 ± 0
Nonmosaic_IV	0.008 ± 0	0.004 ± 0	0.0267 ± 0.0092	0.016 ± 0
Nonmosaic_V	0.008 ± 0	0.004 ± 0	0.032 ± 0	0.016 ± 0
Nonmosaic V MNP*	0.008 ± 0	0.004 ± 0	0.0213 ± 0.0092	0.016 ± 0
Nonmosaic IX	0.008 ± 0	0.004 ± 0	0.032 ± 0	0.0213 ± 0.0092
Nonmosaic XII	0.0107 ± 0.0046	0.0053 ± 0.0023	0.032 ± 0	0.0213 ± 0.0092
Nonmosaic XIII	0.032 ± 0	0.008 ± 0	0.032 ± 0	0.016 ± 0
Nonmosaic XXII	0.004 ± 0	0.0027 ± 0.0012	0.0213 ± 0.0092	0.016 ± 0
Mosaic X	0.125 ± 0	0.0107 ± 0.0046	0.125 ± 0	0.125 ± 0
Mosaic XXXIV	0.0637 ± 0.0006	0.008 ± 0	0.125 ± 0	0.0843 ± 0.0352
Mosaic XXXIV E538G	0.0637 ± 0.0006	0.008 ± 0	0.1047 ± 0.0352	0.0843 ± 0.0352
Mosaic XXXIV A501P	1 ± 0	0.25 ± 0	0.016 ± 0	0.016 ± 0
ATCC 49226	0.0267 ± 0.0092	0.0133 ± 0.0046	0.125 ± 0	0.1047 ± 0.0352
WHO F	0.0033 ± 0.0012	0.001 ± 0	0.016 ± 0	0.0133 ± 0.0046
F89	≥4 ± 0	2 ± 0	0.1047 ± 0.0352	0.1047 ± 0.0352

^aMICs were measured in triplicate by the agar dilution method and averages ± SD are shown.