TABLE 1.

Whole-blood pharmacokinetic AUC and C_max parameters of meropenem after subcutaneous administration of 300 mg/kg of body weight in combination with amoxicillin-clavulanate (s.c. at 200/50 mg/kg) in three different murine genetic backgrounds^a

Mouse genetic background	Cmax (μg/ml)	AUC (μg · h/ml)	T>MIC (h)b
TF3157	1.1	1.7	73, 36, 0
C57BL/6	0.03c	0.05c	0, 0, 0
TF 3157 DHP-I KO	6.6	8.8	66, 49, 39

^aAll groups were pretreated with probenecid (orally [p.o.] at 200 mg/kg). s.c., subcutaneous.

^bResults shown are for MICs 1 to 3, which are 230 ng/mol, 625 ng/mol, and 1,250 ng/mol, respectively. The time over MIC (T_>MIC) was calculated taking as a reference the simulated profile of the compound after 3-times-a-day administration for 8 days, and simulation was extended to 200 h.

^cThe concentration measured was close to the threshold of detection. The wild-type and DHP-I KO mouse strains corresponded to a TF3157 genetic background.