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Azole IC50 determinations for AcCYP51. IC50s were determined for fluconazole (filled circles), itraconazole (hollow circles), and voriconazole (bullets). The CYP51 reconstitution assays contained 0.6 μM AcCYP51 and 1.8 μM AfCPR1 using 50 μM obtusifoliol as the substrate. Relative velocities of 1.00 corresponded to actual velocities of 0.474 ± 0.025/min. The mean values of two replicates are shown along with the associated standard deviation bars.
