TABLE 1.
Susceptibility results for Enterobacteriaceae, P. aeruginosa, and A. baumannii isolates collected in surveillance study
| Species and drug(s) | MIC50 (μg/ml) | MIC90 (μg/ml) | MIC range (μg/ml) | % susceptible |
|---|---|---|---|---|
| E. coli (n = 2,778) | ||||
| Ertapenem | 0.008 | 0.03 | ≤0.002 to >32 | 99.6 |
| Imipenem | 0.25 | 0.25 | ≤0.03 to >32 | 99.9 |
| Imipenem + relebactam | 0.25/4 | 0.25/4 | ≤0.03/4 to 1/4 | 100 |
| K. pneumoniae (n = 891) | ||||
| Ertapenem | ≤0.125 | 8 | ≤0.125 to >8 | 86 |
| Imipenem | 0.25 | 4 | 0.06 to >16 | 88 |
| Imipenem + relebactam | 0.25/4 | 0.25/4 | 0.06/4 to 2/4 | 99.3 |
| blaKPC-possessing K. pneumoniae (n = 111) | ||||
| Ertapenem | >8 | >8 | 0.5 to >8 | 2 |
| Imipenem | 16 | >16 | 0.5 to >16 | 9 |
| Imipenem + relebactam | 0.25/4 | 1/4 | 0.12/4 to 2/4 | 97 |
| Enterobacter spp. (n = 211) | ||||
| Ertapenem | ≤0.125 | 0.25 | ≤0.125 to >8 | 93 |
| Imipenem | 0.5 | 1 | ≤0.03 to >16 | 90 |
| Imipenem + relebactam | 0.25/4 | 0.5/4 | ≤0.03/4 to 2/4 | 99 |
| P. aeruginosa (n = 490) | ||||
| Imipenem | 2 | 16 | ≤0.03 to >16 | 70 |
| Imipenem + relebactam | 0.5/4 | 2/4 | ≤0.03/4 to >16/4 | 98 |
| Imipenem-resistant P. aeruginosa (n = 144) | ||||
| Imipenem | 8 | >16 | 4 to >16 | 0 |
| Imipenem + relebactam | 1/4 | 2/4 | 0.25/4 to >16/4 | 92 |
| A. baumannii (n = 158) | ||||
| Imipenem | 4 | >16 | ≤0.03 to >16 | 49 |
| Imipenem + relebactam | 2/4 | >16/4 | ≤0.03/4 to >16/4 | 51 |
| blaOXA-23-possessing A. baumannii (n = 58) | ||||
| Imipenem | >16 | >16 | ≤0.03 to >16 | 12 |
| Imipenem + relebactam | >16/4 | >16/4 | ≤0.03/4 to >16/4 | 12 |