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. 2015 Jul 16;59(8):5080–5083. doi: 10.1128/AAC.00345-15

TABLE 1.

Statistical analysis of the 620 P. falciparum Thai isolates and K1 strain in vitro responses (IC50 in µM) to doxycycline by year

Parameter Value
2001 2002 2003 2007 2008 2009 2010
Plasmodium falciparum clinical isolates
    No. of isolates 173 244 91 31 24 45 12
    Minimum IC50 2.37 0.83 0.21 7.89 9.04 7.08 14.42
    25% percentile 11.99 9.66 5.13 12.05 11.66 15.91 17.41
    Median 14.56 12.45 8.93 14.77 14.56 17.79 19.86
    75% percentile 18.44 16.01 12.71 17.82 19.13 20.16 21.17
    Maximum IC50 29.28 55.44 30.48 21.5 27.33 33.36 29.26
    Mean 15.16 13.44 9.61 15.08 15.89 18.37 19.93
    SD 5.20 7.27 6.04 3.60 5.10 5.05 3.67
    SE 0.40 0.47 0.63 0.64 1.042 0.75 1.06
    Lower 95% CI of mean 14.38 12.52 8.36 13.76 13.73 16.86 17.6
    Upper 95% CI of mean 15.94 14.36 10.87 16.4 19.89 16.86 22.26
Plasmodium falciparum K1 clone
    No. of isolates 6 6 7 4 4 10 6
    25% percentile 15.82 13.81 8.59 11.79 8.54 15.89 17.52
    Median 17.47 14.37 8.9 12.04 11.33 18.60 18.60
    75% percentile 18.85 15.06 9.54 12.28 13.76 21.93 19.31