TABLE 3.
Statistical analysis of the doxycycline IC50s (in µM) based on the pftetQ and pfmdt copy numbers and PfTetQ KYNNNN repeat numbers in 89 Plasmodium falciparum isolates
| Parameter | Value |
|||||
|---|---|---|---|---|---|---|
| No. of pftetQ copies |
No. of pfmdt copies |
No. of PfTetQ KYNNNN repeats |
||||
| 1 | >1 | 1 | >1 | <3 | 3 | |
| No. of isolates | 86 | 3 | 77 | 11 | 18 | 71 |
| Minimum IC50 | 2.17 | 15.20 | 2.17 | 2.58 | 3.03 | 2.17 |
| 25% percentile | 4.34 | 15.20 | 4.33 | 4.44 | 4.59 | 4.44 |
| Median IC50 | 14.62 | 25.88 | 14.68 | 14.9 | 14.64 | 14.68 |
| 75% percentile | 24.15 | 29.38 | 25.11 | 25.88 | 27.08 | 23.73 |
| Maximum IC50 | 55.44 | 29.38 | 55.44 | 36.92 | 36.92 | 55.44 |
| Mean | 15.66 | 23.49 | 15.85 | 16.49 | 16.99 | 15.65 |
| SD | 11.08 | 7.39 | 11.21 | 10.87 | 11.86 | 10.89 |
| SE | 1.20 | 4.27 | 1.28 | 3.28 | 2.79 | 1.29 |
| Lower 95% CI of mean | 13.28 | 5.14 | 13.30 | 9.19 | 13.92 | 14.87 |
| Upper 95% CI of mean | 18.03 | 41.84 | 18.39 | 23.79 | 20.71 | 16.43 |
| Mann-Whitney test P value | 0.11 | 0.87 | 0.72 | |||