Table 1. Body weight of 9-day-old mice with different genotypes.

	Group 1	Group 2	Group 3	Group 4
	RNF5WT/CFTRWT	RNF5WT/CFTR∆F508	RNF5KO/CFTRWT	RNF5KO/CFTR∆F508
N. Mice	59	26	101	29
Body weight (g): Mean (sem)	4.74 (0.11)	3.84 (0.18)	4.78 (0.07)	3.91 (0.11)
Body weight (g): Median (min–max)	4.7 (3.2–6.6)	4.0 (1.9–5.4)	4.8 (3.1–6.6)	4.0 (3.0–5.2)
N. Mice with body weight <3 g (%)	0 (0%)	7 (26.9%)**	0 (0%)	0 (0%)

Littermates are males and females, of C57BL/6J genetic background. The quantitative variable “Weight” was dichotomized between mice with RNF5 presence or absence (RNF5WT/CFTR∆F508 and RNF5KO/CFTR∆F508, respectively), and ROC curve analysis identified a cut-off value of ≤2.9 g (i.e. <3 g). Comparison of frequencies of mice with body weight less <3 g. was performed based on the Fisher’s exact test (as the expected frequencies were less than 5), followed by Bonferroni’s correction. A symbol indicates a significant difference compared to Group 4; **P < 0.01.