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. 2015 Jul 17;5:10572. doi: 10.1038/srep10572

Figure 2. Mutations in viral miR-122 response elements are correlated with viral DNA loads and disease progression in HBV-infected patients.

Figure 2

(a) The frames indicate mutations in the miR-122 response elements in the HBV genome of virus isolates from HBV-infected patients. The number of patients infected with HBV containing wild type or mutant miR-122 response elements and the mutation frequency in patients are shown. (b–e) Distribution of serum HBV DNA loads (b), HBsAg levels (c) HBeAg status (d) and ALT and AST levels (e) in in CHB and ALCF patients infected with HBV containing wild type or mutant miR-122 response elements. Pearson’s χ2 test was used to determine P values. *, P < 0.05; **, P < 0.01.