Table 1. Clinical and virologic characteristics of CHB-M, CHB-S, and ACLF patients.
| characteristic | CHB-M | CHB-S | ALCF | P value |
|---|---|---|---|---|
| No. of patients | 186 | 119 | 138 | |
| Mean ± SD age (yr) | 40.82 ± 13.46 | 38.65 ± 13.23 | 46.28 ± 11.87 | <0.01 |
| Gender (no. of M/no. of F) | 162/24 | 101/18 | 102/36 | 0.0575 |
| No.(%) of patients with the miR-122 MRE variation | 16(8.6) | 12(10.1) | 15(10.9) | 0.976 |
| No.(%) of patients with HBeAg positive | 115(61.8) | 49(41.2) | 39(28.3) | <0.01 |
| No. of HBV DNA copies/ ml | ||||
| Mean | 1.64 × 107 | 1.39 × 107 | 1.3 × 107 | 0.682 |
| Range | 1020-1.6 × 109 | 500-2.64 × 108 | 505-5.3 × 108 | |
| Mean ± SD (IU/liter) | ||||
| ALT | 128.8 ± 192.1 | 456.5 ± 377.1 | 257.7 ± 388.4 | <0.01 |
| AST | 99.2 ± 114.3 | 289.3 ± 269.6 | 293. ± 426.4 | <0.01 |
HBV, hepatitis B virus; CHB-M, mild chronic hepatitis B; CHB-S, severe chronic hepatitis B; ACLF, acute-on-chronic liver failure; M, male; F, female; HBeAg, hepatitis B virus e antigen; ALT, alanine aminotransferase; AST, aspartate aminotransferase.