TABLE 3.
Antimicrobial activity of Hc-CATH
CI, clinically isolated strain. The results represent the mean values of three independent experiments.
| Microorganisms | MIC |
||
|---|---|---|---|
| Hc-CATH | Meropenem | Ampicillin | |
| μg/ml | |||
| Gram-negative bacteria | |||
| E. coli ATCC25922 | 2.34 (0.64 μm) | 0.01 (0.03 μm) | 4.69 (12.62 μm) |
| E. coli 1 (CI) | 2.34 (0.64 μm) | 0.12 (0.31 μm) | 9.38 (25.24 μm) |
| E. coli 2 (CI) | 2.34 (0.64 μm) | 0.06 (0.15 μm) | >200 |
| E. coli 3 (CI) | 2.34 (0.64 μm) | 0.03 (0.08 μm) | >200 |
| E. coli 4 (CI) | 9.38 (2.59 μm) | 0.12 (0.31 μm) | >200 |
| S. dysenteriae (CI) | 0.59 (0.16 μm) | 0.03 (0.08 μm) | 75.00 (201.90 μm) |
| K. pneumoniae 1 (CI) | 37.50 (10.33 μm) | 0.06 (0.15 μm) | >200 |
| K. pneumoniae 2 (CI) | 4.69 (1.29 μm) | 0.06 (0.15 μm) | >200 |
| K. pneumoniae 3 (CI) | 9.38 (2.59 μm) | 0.06 (0.15 μm) | >200 |
| K. pneumoniae 4 (CI) | 9.38 (2.59 μm) | 0.06 (0.15 μm) | >200 |
| K. pneumoniae 5 (CI) | 18.75 (5.17 μm) | 0.12 (0.31 μm) | >200 |
| K. pneumoniae 6 (CI) | 37.50 (10.33 μm) | 0.12 (0.31 μm) | >200 |
| K. pneumoniae 7 (CI) | 37.50 (10.33 μm) | 0.12 (0.31 μm) | >200 |
| K. pneumoniae 8 (CI) | 75.00 (20.67 μm) | 0.12 (0.31 μm) | >200 |
| Serratia marcescens (CI) | >200 | 0.06 (0.15 μm) | 37.50 (100.90 μm) |
| Klebsiella oxytoca (CI) | 4.69 (1.29 μm) | 0.12 (0.31 μm) | >200 |
| Proteus vulgaris (CI) | >200 | 0.23 (0.61 μm) | 18.75 (50.49 μm) |
| Proteus mirabilis (CI) | 4.69 (1.29 μm) | 0.47 (1.22 μm) | 75.00 (201.90 μm) |
| Acinetobacter baumannii 1 (CI) | >200 | 0.23 (0.61 μm) | 37.50 (100.90 μm) |
| A. baumannii 2 (CI) | >200 | 0.23 (0.61 μm) | 9.38 (25.24 μm) |
| Stenotrophomonas maltophilia 1 (CI) | >200 | 4.69 (12.22 μm) | 18.75 (50.49 μm) |
| S. maltophilia 2 (CI) | 9.38 (2.59 μm) | 4.69 (12.22 μm) | >200 |
| Pseudomonas aeruginosa ATCC27853 | 18.75 (5.17 μm) | 0.06 (0.15 μm) | >200 |
| P. aeruginosa 1 (CI) | 37.50 (10.33 μm) | 0.06 (0.15 μm) | 9.38 (25.24 μm) |
| P. aeruginosa 2 (CI) | >200 | 1.88 (4.89 μm) | >200 |
| Salmonella paratyphi A (CI) | 4.69 (1.29 μm) | 0.12 (0.31 μm) | >200 |
| Gram-positive bacteria | |||
| S. aureus ATCC25923 | 4.69 (1.29 μm) | 0.06 (0.15 μm) | 9.38 (25.24 μm) |
| S. aureus 1 (CI) | >200 | 0.06 (0.15 μm) | 18.75 (50.49 μm) |
| S. aureus 2 (CI) | >200 | 0.12 (0.31 μm) | >200 |
| S. aureus 3 (CI) | >200 | 18.75 (48.9 μm) | >200 |
| S. aureus 4 (CI) | 4.69 (1.29 μm) | 0.12 (0.31 μm) | 9.38 (25.24 μm) |
| S. aureus 5 (CI) | 4.69 (1.29 μm) | 0.06 (0.15 μm) | 9.38 (25.24 μm) |
| Bacillus cereus (CI) | 9.38 (2.59 μm) | 0.06 (0.15 μm) | >200 |
| Bacillus subtilis (CI) | 75.00 (20.67 μm) | 0.03 (0.08 μm) | 75.00 (201.90 μm) |
| Enterococcus faecium (CI) | 37.50 (10.33 μm) | 9.38 (24.45 μm) | >200 |
| Nocardia asteroides (CI) | 9.38 (2.59 μm) | 4.69 (12.22 μm) | 18.75 (50.49 μm) |
| Enterococcus faecalis (CI) | >200 | 9.38 (24.45 μm) | 37.50 (100.90 μm) |
| Staphylococcus epidermidis (CI) | >200 | 0.94 (2.45 μm) | >200 |
| Fungi | |||
| Candida albicans 1 (CI) | 4.69 (1.29 μm) | 0.12 (0.31 μm) | >200 |
| C. albicans 2 (CI) | 4.69 (1.29 μm) | 0.23 (0.61 μm) | >200 |
| C. albicans 3 (CI) | 4.69 (1.29 μm) | 0.06 (0.15 μm) | >200 |
| C. albicans 4 (CI) | 4.69 (1.29 μm) | 0.12 (0.31 μm) | 18.75 (50.49 μm) |
| C. albicans 5 (CI) | 2.34 (0.64 μm) | 0.06 (0.15 μm) | >200 |
| C. albicans 6 (CI) | 2.34 (0.64 μm) | 0.03 (0.08 μm) | >200 |
| Candida glabrata 1 (CI) | 2.34 (0.64 μm) | 0.03 (0.08 μm) | 18.75 (50.49 μm) |
| C. glabrata 2 (CI) | >200 | 0.06 (0.15 μm) | >200 |
| Cryptococcus neoformans (CI) | >200 | 0.47 (1.22 μm) | 4.69 (12.62 μm) |
| Arcyria cinerea | 9.38 (2.59 μm) | 0.12 (0.31 μm) | >200 |
| Aquatic pathogenic bacteria | |||
| Aeromonas sobria | 2.34 (0.64 μm) | 0.03 (0.08 μm) | >200 |
| Aeromonas hydrophila | 2.34 (0.64 μm) | 0.06 (0.15 μm) | >200 |
| Aeromonas veronii | 2.34 (0.64 μm) | 0.03 (0.08 μm) | >200 |
| Vibrio vulnificus | 4.69 (1.29 μm) | 0.12 (0.31 μm) | 75.00 (201.90 μm) |
| Vibrio harveyi | 9.38 (2.59 μm) | 0.03 (0.08 μm) | 37.50 (100.90 μm) |
| Vibrio fluvialis | 4.69 (1.29 μm) | 0.23 (0.61 μm) | 75.00 (201.90 μm) |
| Vibrio alginolyticus | 4.69 (1.29 μm) | 0.12 (0.31 μm) | >200 |
| Vibrio parahaemdyticus | 9.38 (2.59 μm) | 0.47 (1.22 μm) | 18.75 (50.49 μm) |
| Vibrio splendidus | 2.34 (0.64 μm) | 0.47 (1.22 μm) | >200 |
| Vibrio anguillarum | 18.75 (5.17 μm) | 0.23 (0.61 μm) | >200 |
| Edwardsiella tarda | 2.34 (0.64 μm) | 0.12 (0.31 μm) | >200 |