TABLE 5.
Killing kinetics of Hc-CATH against E. coli ATCC25922
E. coli ATCC25922 was mixed with Hc-CATH at a concentration of 5 × MIC for 0, 10, 20, 30, 45, 60, 90, 120, and 180 min. The MICs of Hc-CATH and meropenem against E. coli ATCC25922 are 2.34 and 0.01 μg/ml, respectively. The results represent mean values of three independent experiments.
| Peptide | Time |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| 0 min | 10 min | 20 min | 30 min | 45 min | 60 min | 90 min | 120 min | 180 min | |
| ×103 cfu/ml | |||||||||
| Hc-CATH | 75 ± 11.0 | 39 ± 5.0 | 42 ± 28.5 | 21 ± 5.3 | 6 ± 5.0 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 | 0 ± 0.0 |
| Meropenem | 78 ± 8.7 | 98 ± 11.7 | 82 ± 12.1 | 90 ± 14.9 | 63 ± 40.7 | 69 ± 15.5 | 1 ± 1.7 | 0.3 ± 0.6 | 0 ± 0.0 |
| Control | 93 ± 8.1 | 81 ± 20.8 | 96 ± 10.1 | 104 ± 30.5 | 96 ± 42.6 | 168 ± 17.9 | 387 ± 20.1 | 637 ± 115.8 | 1104 ± 145.7 |