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. 2015 May 13;290(27):16772–16785. doi: 10.1074/jbc.M115.642041

FIGURE 5.

FIGURE 5.

IGF2 overexpression leads to islet macrophage infiltration. A, macrophage infiltration was determined by LGAL3/MAC-2 immunostaining on islet sections from 3-month-old mice. Original magnification ×10 (scale bar, 100 μm) and insets ×40 (scale bar, 50 μm). B, quantification of LGAL3/MAC-2-positive area. Data are expressed as mean ± S.E. of percentage of LGAL3/MAC-2-positive islet areas/total islet areas. n = 5 animals/group. WT (white bars) and Tg-IGF2 (black bars). C, analysis of gene expression by qPCR of histocompatibility 2, class II antigen Aα (H2-Aa), β-2 microglobulin (B2-m) genes in WT (white bars), and Tg-IGF2 (black bars) islets from 4-month-old mice. Results are expressed as mean ± S.E. of at least three pools of islets from eight animals/group. *, p < 0.05; **, p < 0.01.