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. 2015 May 6;290(25):15380–15389. doi: 10.1074/jbc.R115.658823

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

Author's Choice—Final version free via Creative Commons CC-BY license.

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FIGURE 3. — Abbreviated pathway for the biosynthesis and turnover of 1-deoxy-sphingoid bases and traditional sphingoid bases. This scheme summarizes the steps of de novo biosynthesis of traditional sphingoid bases (sphinganine and sphingosine) in red, as well as their turnover via phosphorylation and cleavage. The carbons from palmitate are shown in blue. The analogous metabolic steps are shown in green, as far as they are thought to occur-for 1-deoxysphinganine (produced from alanine) and 1-(deoxymethyl)sphinganine (produced from glycine, not shown). The dashed line indicates the known N-methylation of sphingoid bases, which might also occur for 1-deoxy-sphingoid bases, but this has not yet been established. For more information, see the text and Ref. 4.