TABLE 1.
Plasma cholesterol and triglycerides
Fasting plasma cholesterol and triglyceride concentrations were obtained from equal numbers of male and female mice fed a chow diet for 12 weeks.
Lipoprotein/Lipida | C57BL/6 | PCPE2−/− |
---|---|---|
mg/dl | mg/dl | |
Plasma cholesterol | 79 ± 14b | 121 ± 29c |
VLDL-C | 3 ± 1b | 5 ± 3b |
LDL-C | 14 ± 3b | 12 ± 4b |
HDL-C | 55 ± 8b | 86 ± 21c |
Plasma triglycerides | 69 ± 11b | 78 ± 8b |
ApoA-I | 55 ± 14b | 98 ± 18c |
a Each lipoprotein cholesterol and apoprotein value represents the mean ± S.D. of n = 6 mice/genotype. Lipoproteins were purified by a combination of ultracentrifugation and FPLC. Their lipid and protein content was determined as described under “Experimental Procedures.” Statistical differences at p < 0.05 for each row are indicated by different letters.