TABLE 2.

Chow diet versus atherogenic diet

Fasting plasma cholesterol and fasting triglyceride concentrations were obtained from age-matched male mice fed a chow diet or an atherogenic diet for 12 weeks.

Lipoprotein/Lipidsa	Chow diet		Atherogenic diet
	LDLr−/−	LDLr−/− PCPE2−/−	LDLr−/−	LDLr−/− PCPE2−/−
	mg/dl	mg/dl	mg/dl	mg/dl
Total cholesterol	230 ± 30b	300 ± 34c	1248 ± 109d	1520 ± 50e
VLDL-C	5 ± 1b	4 ± 2b	448 ± 252c	703 ± 257d
LDL-C	92 ± 7b	88 ± 1b	583 ± 209c	631 ± 126c
HDL-C	48 ± 6b	67 ± 8c	52 ± 11b	131 ± 17d
Triglycerides	190 ± 12b	230 ± 30b	310 ± 57d	601 ± 43e

^a Each lipoprotein cholesterol value represents the mean ± S.D. of values from n = 6 mice/genotype. Lipoproteins were purified by a combination of ultracentrifugation and FPLC and their lipid content determined as described under “Experimental Procedures.” Statistical differences at p < 0.05 for each row are indicated by different letters.