FIGURE 3.

Glucose metabolism in FoxO6-KO mice on high fat diet. A, growth curve. Mice were fed a high fat diet at 4 weeks of age for 16 weeks. Body weight was determined weekly. B, fat mass. Fat mass was determined by MRI. C, lean mass. Lean mass was determined by MRI. D, food intake. Food intake per mouse during a 24-h period was determined for two consecutive days. E, blood glucose levels. Fed blood glucose levels were determined in fed states, and fasting blood glucose levels were determined after 16-h fasting. F, glucose tolerance test. Data were obtained from high fat-fed male FoxO6-KO (n = 9) and age/sex-matched WT littermates (n = 8) at 20–22 weeks of age. *, p < 0.05 versus WT control.