TABLE 1.

Regulated proteins identified in the hippocampal synaptic membrane fraction

For each protein, the UniProt protein accession and official gene symbol are listed, together with the number of unique peptides quantified in two sets of iTRAQ experiments (a and b). Strain differences were analyzed by two statistical methods (SAM using permutations to address the multiple testing problem and Newman-Keuls test). Proteins with a q value (SAM) of <10% and a p value (Newman-Keuls) of <0.05 were considered differentially expressed. The differential expression of DBA compared with C57 is indicated as a change on a log2 scale. The proteins are grouped according to molecular function as used for the overrepresentation analysis (cf. Fig. 2).