FIGURE 13.

Probability landscape generated by sorting frames of the MD simulations according to two measurements as follows: x axis, distance between the center-of-mass of the side chain of residue Phe⁸ and the center-of-mass of the side chains of residues V108^3.32, L112^3.36, F77^2.53, I288^7.39, A291^7.41, and Y292^7.42 of the hydrophobic core; y axis, graphs on the left, distance between the center-of-mass of backbone atoms of residues V108³²–L112^3.36 (region of the hydrophobic core on TMD3) and residues I288^7.39–Y292^7.43 (region of the hydrophobic core on TMD7); y-axis, graphs on the right, r.m.s.d. of the Cα atoms of residues I288^7.39 through N295^7.46 on TMD7.