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Probability landscape generated by sorting frames of the MD simulations according to two measurements as follow: x axis, distance between the center-of-mass of backbone atoms of residues V1083.32–L1123.36 (region of the hydrophobic core on TMD3) and residues I2887.39–Y2927.43 (region of the hydrophobic core on TMD7); y axis, r.m.s.d. of the Cα atoms of residues I2887.39 through N2957.46 on TMD7.
