FIGURE 4.

Induction of CETP expression is associated with inhibition of Topo IIA expression. A and B, HepG2 cells were transfected with scrambled siRNA or Topo IIA siRNA followed by determination of Topo IIA and CETP protein and mRNA expression, respectively. C, 293T cells were transfected with Topo IIA siRNA for 48 h. The cells were then transfected with pCETP plus LXRα expression vector for 6 h. After treatment with teniposide for 16 h, pCETP promoter activity was determined. C2, pEGFP-C2 vector; LXRα, pEGFP-LXRα expression vector. * and **, versus control in the corresponding groups at p < 0.05 (n = 3).