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. 2015 Apr 25;290(23):14418–14429. doi: 10.1074/jbc.M115.643015

FIGURE 6.

FIGURE 6.

Teniposide induces liver CETP expression and RCT in CETP transgenic mice. Both wild type (WT) and CETPtg (CETP) mice (5/group) were subcutaneously injected with teniposide solution twice (15 mg/kg bodyweight, once every 4 days). 8 days after of the first injection of teniposide, all the mice were conducted in an RCT assay by intraperitoneal injecting with radiolabeled peritoneal macrophages isolated from the corresponding type mice. Both blood (wild type and CETPtg mice) and liver (CETPtg mice) samples were collected in the following assays. A, serum lipid profiles in both wild type and CETPtg mice. Teni, teniposide. B, expression of MTTP mRNA in the liver of both wild type and CETPtg mice was determined by real time RT-PCR. *, p < 0.05 (n = 5). C and D, expression of CETP mRNA and protein in the liver of CETPtg mice was determined by real-time RT-PCR, Western blot, and immunohistochemical staining. E, fecal samples from each mouse were individually collected at the indicated times after injection of radiolabeled macrophages, and excreted radioactivity was determined. §, versus wild type mice; *, versus control within same type of mice at p < 0.05 (n = 5).