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. 2015 Apr 23;290(23):14567–14581. doi: 10.1074/jbc.M114.622191

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 1. — Z-551 is a novel PPAR modulator having both PPARα agonistic and PPARγ antagonistic activities. A and B, chemical structures of Z-551 (A) and CZD-2 (B). C and D, effects of Z-551 and CZD-2 on transcriptional activities for mouse PPARα (C) and PPARγ (D). All results are expressed as mean ± S.E. (n = 4). EC₅₀ values for PPARα are calculated on the assumption that the maximum transcriptional activity induced by Wy-14643 is 100%. IC₅₀ values for PPARγ are calculated on the assumption that the transcriptional activity induced by 100 nm rosiglitazone is 100%.