FIGURE 6.

Inhibition of adipocyte differentiation by CD45⁺CD11b⁺CD11c⁺ myeloid cells. A, increased adipogenesis in preadipocytes treated with BM-DC-conditioned medium from Mmp12^−/− mice. B, increased adipogenesis in preadipocytes treated with conditioned medium from BM-DCs in which Fn1 had been silenced. Both experiments were repeated four times, and representative experiments are presented. C, inhibition of adipogenesis when preadipocytes are co-cultured with CD45⁺CD11b⁺CD11c⁺ cells. The experiment was repeated three times. D–F, panel of adipogenesis genes for the CD45⁺CD11b⁺CD11c⁺ co-culture experiments.