TABLE 5.
Organ cross-reactivity of hu3F8 scFv variants by immunohistochemistry
The strength is defined as follows: negative (−); weak, heterogeneous membrane staining (+); weak, homogeneous membrane staining (++); strong, heterogeneous membrane staining (+++); strong, homogeneous membrane staining (++++).
| Organ | hu3F8a | D32Ha | E1K/D32Ha |
|---|---|---|---|
| NBb | ++++ | ++++ | ++++ |
| Ileum | − | − | − |
| Skeletal muscle | − | − | − |
| Cerebellum | − | + | + |
| Frontal lobe | − | + | + |
| Pons | − | + | + |
| Stomach | − | − | − |
| Spinal cord | − | + | + |
| Lung | − | − | − |
| Spleen | − | − | − |
| Thyroid | − | − | − |
| Kidney | − | − | − |
| Testes | − | − | − |
a scFv concentration is 3 μg/ml.
b Stage 4 neuroblastoma tumor.