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Two-step model for disassembly of the ESCRT-III complex by Vps4. The active Vps4 hexamer is shown with one subunit colored green. ESCRT-III substrates are recognized by binding of their MIM elements to Vps4 MIT domains, which release MIT/linker-mediated autoinhibition and allow the Vps4 pore loops (red) to engage a high affinity binding site on helix 5 of the ESCRT-III subunits and initiate translocation.
