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. 2015 Apr 7;290(21):13521–13530. doi: 10.1074/jbc.M115.642868

FIGURE 5.

FIGURE 5.

PKCδ and p38δ regulate MEP50 and PRMT5 level and activity. A, KERn were infected with tAd5-EV, Ad5-PKCδ, or tAd5-HA-p38δ (multiplicity of infection (MOI) 10), and, at 48 h, extracts were prepared for detection of PKCδ, MEP50, H3R8me2s, and H4R3me2s. Similar results were obtained in three different experiments. EV, empty vector. B and C, KERn were infected as above, and, at 48 h, extracts were prepared for ChIP using primers spanning the p21Cip1 promoter region that includes the p53-2 site. The values are mean ± S.E. (n = 3). *, p < 0.005).