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. Author manuscript; available in PMC: 2015 Oct 1.
Published in final edited form as: Sci Transl Med. 2015 Apr 1;7(281):281ra43. doi: 10.1126/scitranslmed.aaa2293

Figure 1. Different immunological profiles in aging versus CMV seropositivity.

Figure 1

The contribution of age and CMV to immunological and gene expression profiles was estimated by a combination of nuclear norm and the Elastic net methods (see Methods). The magnitude of the regression coefficients used to separate the classes yCMV− and oCMV− (CMV-independent age effect) or yCMV− and yCMV+ (age-independent CMV effect) are shown in light and dark grey bars, respectively. Only two parameters, the frequency of CD8+ CD28− and CD8+ TEM cells, overlapped between these classification tasks. 14/16 (87.5%) of the parameters used to separate the yCMV− from yCMV+ classes were up-regulated in CMV, in contrast, the majority of parameters used to separate the yCMV− from oCMV− classes (16/23, 69.5%) were down-regulated in aging.