Table 2.
Progression of autonomic dysregulation and left ventricular dysfunction in individual Sgcd−/− mice studied at 10, 30, 50, and 75 weeks of age.
| Sgcd−/− Mice | BRS (ms/mmHg) | Vagal Tone (Δbpm) | Sympathetic Tone (Δbpm) | EF (%) | EDV (μl) | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 | 30 | 50 | 75 | 10 | 30 | 50 | 75 | 10 | 30 | 50 | 75 | 10 | 30 | 50 | 75 | 10 | 30 | 50 | 75 | |
|
| ||||||||||||||||||||
| Mouse #1 | 0.62 | 0.29 | x | x | +16 | +4 | x | x | −212 | −301 | x | x | 72 | 44 | x | x | 30 | 39 | x | x |
| Mouse #2 | 0.69 | 0.36 | x | x | +30 | +18 | x | x | −171 | −230 | x | x | 79 | 45 | x | x | 29 | 34 | x | x |
| Mouse #3 | 1.38 | 1.23 | 0.70 | x | +51 | +46 | +21 | x | −166 | −256 | −304 | x | 86 | 62 | 40 | x | 28 | 22 | 46 | x |
| Mouse #4 | 0.99 | 0.95 | 0.49 | x | +100 | +60 | +12 | x | −101 | −139 | −271 | x | 86 | 84 | 66 | x | 26 | 25 | 42 | x |
| Mouse #5 | 1.65 | 1.50 | 0.93 | 0.53 | +40 | +30 | +25 | +10 | −158 | −164 | −180 | −307 | 86 | 73 | 72 | 34 | 21 | 20 | 30 | 42 |
| Mouse #6 | 0.77 | 1.11 | 0.71 | 0.56 | +53 | +45 | +40 | +39 | −96 | −114 | −150 | −182 | 86 | 85 | 76 | 47 | 22 | 20 | 27 | 35 |
| Mouse #7 | 0.85 | 0.93 | 0.62 | 0.33 | +26 | +17 | +9 | −1 | −92 | −106 | −156 | −281 | 86 | 85 | 80 | 37 | 28 | 20 | 29 | 53 |
| Mouse #8 | 0.80 | 0.92 | 0.88 | 0.70 | +45 | +40 | +10 | +17 | −87 | −90 | −104 | −130 | 82 | 82 | 79 | 58 | 25 | 20 | 26 | 38 |
The mice are arranged in order of lifespan and cardiac sympathetic tone. Sgcd−/− mice that died (indicated with an ‘x’) during the study were Mouse #1 at 31 weeks of age, Mouse #2 at 37 weeks, Mouse #3 at 53 weeks, and Mouse #4 at 56 weeks. BRS, baroreflex sensitivity; Vagal Tone, HR response to methylatropine; Sympathetic Tone, HR response to propranolol; EF, left ventricular ejection fraction; EDV, left ventricular end-diastolic volume