TABLE 1.
Genetic diversity of human herpesviruses
| Subfamily | Speciesa | No. of strainsb | Overall mean distance (substitutions/site) | Standard errorc | Transition/transversion ratio |
|---|---|---|---|---|---|
| Alphaherpesvirinae | HHV-1 (HSV-1) | 26 | 0.0076 | 0.000079 | 1.63 |
| HHV-2 (HSV-2) | 2 | 0.0041 | 0.000083 | 1.29 | |
| HHV-3 (VZV) | 46 | 0.0014 | 0.000040 | 2.01 | |
| Betaherpesvirinae | HHV-5 (HCMV) | 124 | 0.0266 | 0.000100 | 2.53 |
| HHV-6A | 2 | 0.0135 | 0.000380 | 1.88 | |
| HHV-6B | 2 | 0.0070 | 0.000138 | 1.81 | |
| HHV-7 | 2 | 0.0013 | 0.000084 | 2.80 | |
| Gammaherpesvirinae | HHV-4 (EBV) | 9 | 0.0087 | 0.000086 | 1.36 |
| HHV-8 (KSHV) | 3 | 0.0021 | 0.000066 | 1.05 |
a
The official taxonomic names (human herpesvirus 1 [HHV-1] to HHV-8) are given, followed by common names in parentheses, if available. HSV-1, herpes simplex virus 1; VZV, varicella-zoster virus; HCMV, human cytomegalovirus; EBV, Epstein-Barr virus; KSHV, Kaposi sarcoma-associated herpesvirus.
b
GenBank accession numbers for strains used in genome alignments are listed in Table S1 in the supplemental material; data for the HSV-1 alignment were reported previously (48).
c
Standard errors were calculated from 500 bootstrap replicates.