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. 2015 May 13;89(15):7673–7695. doi: 10.1128/JVI.00578-15

TABLE 3.

Most conserved HCMV genes

Gene dNa Gene familyb Gene conservationc Function(s)d
UL46 0.000 NA Core Virion protein
UL85 0.000 NA Core Assembly
UL103 0.000 NA Core Virion protein, assembly
US18 0.000 US12 No Unknown
UL26 0.001 US22 No Virion protein, gene regulation, virion stability
UL29 0.001 US22 Beta Virion protein,e gene regulation, apoptosis, cell tropism
UL31 0.001 DURP Beta Gene regulation
UL35 0.001 UL25 Beta Gene regulation,e replication, nucleotide repair, assembly, virion protein
UL41A 0.001 NA No Virion protein
UL44 0.001 NA Core Host modulation, replication, latencye
UL50 0.001 NA Core Virion protein,e latency,e assembly
UL57 0.001 NA Core Replication
UL79 0.001 NA Betagamma Gene regulation, latencye
UL86 0.001 NA Core Assembly
UL88 0.001 NA Betagamma Virion protein, assemblye
UL89 0.001 NA Core Viral growth, assembly
UL96 0.001 NA Core Virion protein, assembly
UL98 0.001 NA Core Nucleotide repair, latencye
UL102 0.001 NA Core Replication
UL104 0.001 NA Core Assembly
UL105 0.001 NA Core Replication, latencye
UL114 0.001 NA Core Nucleotide repair, replication, latencye
US13 0.001 US12 No Unknown
US24 0.001 US22 No Virion protein, gene regulation
US31 0.001 US1 No Unknown
a

dN, nonsynonymous substitutions per nonsynonymous site.

b

NA, not assigned to a gene family.

c

Gene conservation over different herpesvirus subfamilies. Core, conserved in all mammalian herpesviruses; Beta, conserved in all members of the subfamily Betaherpesvirinae; Betagamma, conserved in all members of the subfamilies Betaherpesvirinae and Gammaherpesvirinae; No, not conserved in all members of the subfamily Betaherpesvirinae.

d

Functions of the encoded gene products were reported previously (71).

e

Proposed function, which needs further validation.