TABLE 1.
Effect of CD98hc knockdown on distribution of enveloped HSV-1(F) virus particles in infected HEp-2 cells
| Knockdown cell | No. of invaginations | % of virus particles in morphogenetic stagea |
Total no. (particles/cells) | |||
|---|---|---|---|---|---|---|
| EV in the intranuclear vesicles | EV in the perinuclear space | EV in the cytoplasm | Extracellular EV | |||
| sh-Luc-HEp-2 | 0 | 0 (0) | 9.5 (70) | 28.0 (206) | 62.5 (460) | 736/9 |
| sh-CD98hc-HEp-2 | 15 | 37.4 (274) | 13.8 (101) | 31.6 (231) | 17.2 (126) | 732/10 |
| sh-CD98hc/CD98hc-HEp-2 | 5 | 5.5 (39) | 8.8 (62) | 30.1 (213) | 55.6 (393) | 707/10 |
a
Numbers in parentheses are the numbers of virus particles. EV, enveloped virions.