FIG 8.

PPS treatment alters soluble factors in CHIKV-induced inflammatory disease. Twenty-five-day-old C57BL/6 mice were infected with CHIKV or diluent alone and then either treated daily i.p. with PPS or mock treated with PBS alone. (A) Kinetics of IL-10 were altered with PPS treatment. The horizontal line represents the level in the mock control. Each bar represents the mean result ± standard error for 5 to 6 mice. *, P < 0.05; **, P < 0.01; ***, P < 0.001; two-way ANOVA with Bonferroni posttest. Asterisks directly on top of bars show comparison to mock control levels. (B) Levels of proinflammatory factors at peak swelling 3 days p.i. were decreased with PPS treatment. *, P < 0.05; **, P < 0.01; ***, P < 0.001; one-way ANOVA with Tukey's posttest.