TABLE 1.

Primer sequences used

Target gene product	Sequence
	Forward	Reverse
TGF-β	CAA CGC CAT CTA TGA GAA AAC C	AAG CCC TGT ATT CCG TCT CC
Aggrecan	GCC CAA GAA CAG TAC AAT GGT	TGC TAG GTT GGT TGA CCC A
Collagen I	CAG AAC ATC ACC TAC CAC TGC AA	TTC AAC ATC GTT GGA ACC CTG
Collagen II	AGA ACA GCA TCG CCT ACC TG	CTT GCC CCA CTT ACC AGT GT
BMP-1/mTLD	AGC AGG CTG CAG TTC TCA GAC AGC	GAA TGT GTT CCG GGC ATA GTG CAT
ADAMTS-4	CAC TGA CTT CCT GGA CAA TGG TTA T	GGA AAA GTC GTC GGT AGA TGG A
ADAMTS-5	GAT GAT CAC GAA GAG CAC TAC GA	TCA CAT GAA TGA TGC CCA CAT
MMP-3	TGG AGC TGA TGC ATA AGC CC	TGA AGC CAC CAA CAT CAG GA
MMP-9	GGA ACT CAC ACG ACA TCT TCC A	GAA ACT CAC ACG CCA GAA GAA TTT
TIMP-3	GGC ACT CTG GTC TAC ACT ATT AAG CA	TTT CAG AGG CTT CCG TGT GA
RRV nsp3 primera	CCG TGG CGG GTA TTA TCA AT	AAC ACT CCC GTC GAC AAC AGA

^aThe RRV nsp3 probe is ATT AAG AGT GTA GCC ATC C.