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. Author manuscript; available in PMC: 2016 Jun 10.
Published in final edited form as: J Am Chem Soc. 2015 Jun 1;137(22):6975–6978. doi: 10.1021/jacs.5b04681

Figure 1.

Figure 1

A) Biosynthesis of lacticin 481 analogs by incorporating Boc-HO-1, HO-2, or HO-3 at position 1 of the core peptide (X) using the amber stop codon suppression method. WT lacticin 481 contains a lysine at position 1. Also, position –1 (green) was mutated from Ala to Ile as described in the text. B) Structures of non-proteinogenic amino and hydroxy acids introduced into lacticin 481 or nukacin ISK-1 at residue 1 (X).