. Author manuscript; available in PMC: 2015 Jul 17.

Published in final edited form as: Cell. 2008 Feb 22;132(4):598–611. doi: 10.1016/j.cell.2008.01.038

Table 1. Characterized invertebrate stem cells and their niches.

Stem cell	Species	Niche type	Major signal	Additional signals	RNAi?	Replaced?	Number/nich e	Targets	Recent Reference
GSC (female)	D. melanogaster	S	JAK- STAT BMP	Notch	Y	Y	2	Bam	(Lopez-Oneiva et al., 2008)
GSC (male)	D. melanogaster	S	JAK- STAT BMP			Y	7-12	Bam	(Yamashita et al., 2007)
Escort stem cell	D. melanogaster	S	JAK STAT	EGFR			4-6		(Gilboa and Lehmann, 2006)
Cyst progenitor	D. melanogaster	S	JAK- STAT?	EGFR?			14- 24		(Brawley and Matunis, 2004)
Follicle stem cell	D. melanogaster	E	Hh	Notch, Dpp, Wg	Y	Y	1		(Nystul and Spradling, 2007)
Intestinal Stem cell	D. melanogaster	E		Notch		Y?	1?		(Ohlstein and Spradling, 2007)
GSC hermaphrodite	C. elegans	S	Notch				50?	Gld1 Gld2 Gld3	(Kimble and Crittenden, 2007)

S = stromal niche; E = epithelial niche;