Fig. 4. Location selectivity requires vHPC input during encoding but not retrieval.

(a) Differences in firing rate with terminal illumination (n=433 units, sign rank z=−0.23, p=0.82; n=359, z=−0.97, p=0.33, for Arch⁺ and Arch⁻ animals, respectively).

(b) Mean binned spike rates for an example mPFC unit from an Arch⁺ animal, aligned to arrival at each of the 4 sample goals (color coded) without (left) or with (right) terminal illumination.

(c) Peri-event firing rates during the sample phase for all location-selective units as they approach the preferred (red/grey) and non-preferred (black) goals (blue asterisks, time points with Bonferroni-corrected significance) during light on (right) and light off (left) trials. n=67 units from 7 Arch⁺ mice, and 78 units from 6 Arch⁻ mice.

(d) Same as (c), but during the choice phase. n=145 units from 7 Arch⁻ mice, and 77 units from 6 Arch⁺ mice.