Table IV.

Calculated $\mathrm{\Delta }{G}_{\text{fold}}^{\text{elec}}$ for the Set of Dielectrics ${\mathrm{\epsilon }}_{\mathrm{p}}^{\prime }=40$ and ${\mathrm{\epsilon }}_{\text{eff}}^{\prime }=40$ for Different Proposed Mutations in the Wild Type Lip A^a

Ionized to non polar mutations of the wild type Lip A
Structures	$\mathrm{\Delta }{G}_{\text{fold}}^{\text{elec}}$
Wild type	−7.62b
Arg142Ala	−9.27
Lys23Ala	−9.61
Lys70Ala	−9.65
Lys88Ala	−9.80
Arg107Ala	−10.15
Arg33Ala	−10.31
Lys23Ala//Arg33Ala	−10.64
Lys23Ala//Arg33Ala//Arg107Ala	−12.43
Non polar to ionized mutations of the wild type Lip A
Structures	$\mathrm{\Delta }{G}_{\text{fold}}^{\text{elec}}$
Wild type	−7.62b
Ala38Asp	−8.53
Ala132Asp	−8.96
Ala105Asp	−9.39
Ala15Asp	−9.52
Ala75Asp	−9.77
Ala81Asp	−9.97
Ala20Asp	−10.78
Ala68Asp	−10.89
Ala146Asp	−11.03
Ala97Asp	−11.21
Ala113Asp	−11.63
Charged to non polar mutations of the most stable mutant (variant XI) of Lip A
Structures	$\mathrm{\Delta }{G}_{\text{fold}}^{\text{elec}}$
Variant XI	−10.30b
Lys32Ala	−10.71
Asp133Ala	−11.08
Lys70Ala	−11.16
Lys23Ala//Lys70Ala	−11.32

^aEnergies in kcal/mol.

^bTaken from Ref. 69.