Table 3.

Essential Non-Homologous Proteins of C.jejuni Similar to Binding Partners of Drugs Available in Drug Bank by Homology Search

No.	Uniprot Id	Gene name	Protein name	Pathway involved	Drug Bank Id	Drug name	Drug group
1	Q9PP26	alr	Alanine racemase	D-Alanine metabolism, Vancomycin resistance	DB01993, DB02142, DB03097, DB03327, DB03579, DB03766, DB03801, DB04467, DB03252, DB03801, DB00260	N-(5′-Phosphopyridoxyl)-D-Alanine, Pyridoxamine-5′-Phosphate, Pmp-Hydroxyisoxazole, Pyridoxamine-5-Phosphate-Hydroxyisoxazole, {1-[(3-Hydroxy-Methyl-5-Phosphonooxy-Methyl-Pyridin-4-Ylmethyl)-Amino]-Ethyl}-Phosphonic Acid, Pyridoxyl-N,O-Cycloserylamide-5-Monophosphate, Propanoic Acid, Lysine Nz-Carboxylic Acid, Pyridoxyl-Alanine-5-Phosphate, D-Lysine, Lysine Nz-Carboxylic Acid, Cycloserine	Experimental (11); Approved
2	Q9PPC2	ddl	D-Alanine–D-alanine ligase	D-Alanine metabolism, Vancomycin resistance, Peptidoglycan biosynthesis	DB00260, DB07805	Cycloserine, 3-chloro-2,2-dimethyl-n-[4-(trifluoromethyl)phenyl]propanamide	Approved; Experimental
3	Q9PIM1	lpxA	Acyl-[acyl-carrier-protein]–UDP-N-acetylglucosamine O-acyltransferase	Lipopolysaccharide biosynthesis	DB01694, DB08558	D-tartaric acid, 2-hydroxymethyl-6-octylsulfanyl-tetrahydro-pyran-3,4,5-triol	Experimental (2)
4	Q9PHU0	lpxD	UDP-3-O-acylglucosamine N-acyltransferase	Lipopolysaccharide biosynthesis	DB01694, DB08558	D-tartaric acid, 2-hydroxymethyl-6-octylsulfanyl-tetrahydro-pyran-3,4,5-triol	Experimental (2)
5	Q9PIZ5	lpxC	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase	Lipopolysaccharide biosynthesis	DB07861, DBo1991, DB04257, DB07355, DB07536, DB08231	(2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide, Tu-514, Palmitoleic Acid, 3-(heptyloxy)benzoic acid, N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide, myristic acid	Experimental (6)
6	Q9PP65	murA	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	Peptidoglycan biosynthesis	DB01879, DB02435, DB02995, DB03089, DB04174, DB04474, DB03397, DB00828,	(S)-2-{Methyl-[2-(Naphthalene-2-Sulfonylamino)-5-(Naphthalene-2-Sulfonyloxy)-Benzoyl]-Amino}-Succinicacid, Aminomethylcyclohexane, Cyclohexylammonium Ion, L-Iso-Aspartate, 3′-1-Carboxy-1-Phosphonooxy-Ethoxy-Uridine-Diphosphate-N-Acetylglucosamine, 1-Anilino-8-Naphthalene Sulfonate, Uridine-Diphosphate-N-Acetylglucosamine, Fosfomycin	Experimental (7); Approved
7	Q9PM01	murB	UDP-N-acetylenolpyruvoylglucosamine reductase	Peptidoglycan biosynthesis	DB03147	Flavin adenine dinucleotide	Approved
8	Q9PNN7	murC	UDP-N-acetylmuramate–L-alanine ligase	Peptidoglycan biosynthesis	DB01673, DB03909, DB04395	Uridine-5′-Diphosphate-N-Acetylmuramoyl-L-Alanine, Adenosine-5′-[Beta, Gamma-Methylene]Triphosphate, Phosphoaminophosphonic Acid-Adenylate Ester	Experimental (3)
9	Q0PA95	murF	UDP-N-acetylmuramoyl-tripeptide D-alanyl-D-alanine ligase	Peptidoglycan biosynthesis, Vancomycin resistance	DB06970	2-chloro-n-(3-cyano-5,6-dihydro-4h-cyclopenta[b]thiophen-2-yl)-5-diethylsulfamoyl-benzamide	Experimental
10	Q0PB07	pbpA	Penicillin-binding protein	Peptidoglycan biosynthesis, beta-Lactam resistance	DB00229, DB00267, DB00301, DB00417, DB00456, DB00713, DB00833, DB00948, DB01000, DB01060, DB01061, DB01066, DB01112, DB01139, DB01147, DB01602, DB01604, DB01605, DB01150, DB00415, DB00438, DB00485, DB00493, DB00567, DB00607, DB01331, DB01603, DB08795, DB00274, DB00430, DB01327, DB01328, DB01329, DB01332, DB01333, DB01414 DB01415, DB01598, DB04570, DB04133, DB03313, DB08375 DB00447, DB01163, DB05659, DB00739, DB01140, DB00303	Cefotiam, Cefmenoxime, Flucloxacillin, Penicillin V, Cefalotin, Oxacillin, Cefaclor, Mezlocillin, Cyclacillin, Amoxicillin, Azlocillin, Cefditoren, Cefuroxime, Cefapirin, Cloxacillin, Bacampicillin, Pivampicillin, Pivmecillinam, Cefprozil, Ampicillin, Ceftazidime, Dicloxacillin, Cefotaxime, Cephalexin, Nafcillin, Cefoxitin, Meticillin, Azidocillin, Cefmetazole, Cefpiramide, Cefazolin, Cefonicid, Cefoperazone, Ceftizoxime, Cefradine, Cefacetrile, Ceftibuten, Imipenem, Latamoxef, Degraded Cephaloridine, Cephalosporin C, Pcnotaxime group, Loracarbef, Amdinocillin, faropenem medoxomil, Hetacillin, Cefadroxil, Ertapenem	Approved (39); Experimental (3); Withdrawn (2); Investigational; Approved, withdrawn (2); Approved, investigational
11	Q0PAS0	fba	Fructose-bisphosphate aldolase	Methane metabolism, Biosynthesis of secondary metabolites, Microbial metabolism in diverse environments	DB03026	Phosphoglycolohydroxamic Acid	Experimental
12	Q9PJ53	aroQ	3-Dehydroquinate dehydratase	Biosynthesis of secondary metabolites	DB03868, DB04698, DB02801, DB03739, DB02786, DB04347, DB04656, DB08485	3-Dehydroquinic Acid, N-(1,4-dihydro-5h-tetrazol-5-ylidene)-9-oxo-9h-xanthene-2-sulfonamide, 2,3 -Anhydro-Quinic Acid, 3-Hydroxyimino Quinic Acid, 2-Anhydro-3-Fluoro-Quinic Acid, 3-Dehydroshikimate, 1,3,4-trihydroxy-5-(3-phenoxypropyl)-cyclohexane-1-carboxylic acid, (1S,4S,5S)-1,4,5-trihydroxy-3-[3-(phenylthio)phenyl]cyclohex-2-ene-1-carboxylic acid	Experimental (8)
13	Q0PC20	pfs	Aminodeoxyfutalosine nucleosidase	Biosynthesis of secondary metabolites	DB07463, DB02158, DB02281, DB02933, DB08606, DB07649, DB02857, DB00173	(3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(butylsulfanyl)methyl]pyrrolidin-3-ol, (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol, Formycin, 5′-Deoxy-5′-(Methylthio)-Tubercidin, 3R,4S)-1-[(4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(methylsulfanyl)methyl]pyrrolidin-3-ol, (3R,4S)-1-[(4-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)methyl]-4-[(benzylsulfanyl)methyl]pyrrolidin-3-ol, Guanosine, Adenine	Experimental (7); Approved, Nutraceutical
14	Q9PIK3	panD	Aspartate 1-decarboxylase	Biosynthesis of secondary metabolites	DB02175, DB03382,	Malonic acid, S-Oxy Cysteine	Experimental (2)
15	Q9PIK2	panC	Pantothenate synthetase	Biosynthesis of secondary metabolites	DB01930, DB02596, DB02694, DB03107	2,4-Dihydroxy-3,3-Dimethyl-Butyrate, Alpha,Beta-Methyleneadenosine-5′-Triphosphate, Pantoyl Adenylate, Beta-Alanine	Experimental (4)
16	Q9PIK1	panB	3-Methyl-2-oxobutanoate hydroxymethyltransferase	Biosynthesis of secondary metabolites	DB03795, DB04074	2-Dehydropantoate, Alpha-ketoisovalerate	Experimental (2)
17	Q0PBJ3	pheA	Chorismate mutase/prephenate dehydratase	Biosynthesis of secondary metabolites	DB08648, DB03884	8-hydroxy-2-oxa-bicyclo[3.3.1]non-6-ene-3,5-dicarboxylic acid, 3-Phenylpyruvic Acid	Experimental (2)
18	Q0PBA5	aroE	Shikimate dehydrogenase	Biosynthesis of secondary metabolites	DB02363, DB03461, DB04447	2′-Monophosphoadenosine-5′-Diphosphate, 2′-Monophosphoadenosine 5′-Diphosphoribose, 1,4-Dithiothreitol	Experimental (3)
19	Q9PI11	trpC	Indole-3-glycerol phosphate synthase	Biosynthesis of secondary metabolites	DB03543	1-(O-Carboxy-Phenylamino)-1-Deoxy-D-Ribulose-5-Phosphate	Experimental
20	P0C632	ispH	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase	Biosynthesis of secondary metabolites	DB01785, DB04714	Dimethylallyl Diphosphate, Isopentenyl Pyrophosphate	Experimental (2)
21	P0C630	aroA	3-Phosphoshikimate 1-carboxyvinyltransferase	Biosynthesis of secondary metabolites	DB04328, DB04539, DB01942, DB03116	Shikimate-3-Phosphate, Glyphosate, Formic Acid, 5-(1-Carboxy-1-Phosphonooxy-Ethoxyl)-Shikimate-3-Phosphate	Experimental (4)
22	Q9PNT2	aroB	3-Dehydroquinate synthase	Biosynthesis of secondary metabolites	DB02592	Carbaphosphonate	Experimental
23	Q9PMV3	dxr	1-Deoxy-D-xylulose 5-phosphate reductoisomerase	Biosynthesis of secondary metabolites	DB02496, DB02948, DB03649, DB04272	1-Deoxy-D-xylulose 5-phosphate, Fosmidomycin, [{(5-Chloro-2-Pyridinyl)Amino} Methylene]-1,1-Bisphosphonate, Citric Acid	Experimental (3); Nutraceutical
24	Q0P8N9	Cj1370		Biosynthesis of secondary metabolites	DB02075	(1s)-1(9-Deazahypoxanthin-9yl)1,4-Dideoxy-1,4-Imino-D-Ribitol-5-Phosphate	Experimental
25	Q9PM41	aroC	Chorismate synthase	Biosynthesis of secondary metabolites	DB03247, DB03350, DB03969, DB04267	Riboflavin Monophosphate, Cobalt Hexammine Ion, 3-Acetyl Pyridine Adenine Dinucleotide, Dipicolinic Acid	Experimental (4)
26	Q9PIT2	dapB	4-Hydroxy-tetrahydrodipicolinate reductase	Biosynthesis of secondary metabolites, Microbial metabolism in diverse environments	DB03969, DB04267	3-Acetyl Pyridine Adenine Dinucleotide, Dipicolinic Acid	Experimental (2)
27	Q0P9X4	rpiB	Ribose 5-phosphate isomerase	Biosynthesis of secondary metabolites, Microbial metabolism in diverse environments	DB03661, DB03108, DB04496	Cysteinesulfonic Acid, 4-Phospho-D-Erythronate, 4-Phospho-D-Erythronohydroxamic Acid	Experimental (3)
28	Q0PAZ1	pbpB	Putative penicillin-binding protein	Peptidoglycan biosynthesis, beta-Lactam resistance	DB00274, DB00430, DB00438, DB01327, DB01328, DB01329, DB01331, DB01332, DB01414, DB01415, DB01598, DB04570, DB00319, DB00415, DB00456, DB00485, DB00493, DB00567, DB00607, DB00713, DB01603, DB08795, DB00303, DB08401, DB03313, DB08508, DB00739, DB01140, DB01163	Cefmetazole, Cefpiramide, Ceftazidime, Cefazolin, Cefonicid, Cefoperazone, Cefoxitin, Ceftizoxime, Cefacetrile, Ceftibuten, Imipenem, Latamoxef, Piperacillin, Ampicillin, Cefalotin, Dicloxacillin, Cefotaxime, Cephalexin, Nafcillin, Oxacillin, Meticillin, Azidocillin, Ertapenem, (2e)-2-({(2s)-2-carboxy-2-[(phenoxyacetyl)amino]ethoxy}imino)pentanedioic acid, Cephalosporin C, N-benzoyl-D-alanine, Hetacillin, Cefadroxil, Amdinocillin	Approved (22); Approved, Investigational; Experimental (3); Approved, withdrawn (2); Withdrawn;
29	Q0PAL6	pbpC	Penicillin-binding protein	Peptidoglycan biosynthesis, beta-Lactam resistance	DB01327	Cefazolin	Approved
30	Q0PBA2	frdC	Fumarate reductase cytochrome B subunit	Biosynthesis of secondary metabolites, Microbial metabolism in diverse environments, Two-component system	DB07669	2,3-dimethyl-1,4-naphthoquinone	Experimental
31	Q0P8D0	ccoP	Cbb3-type cytochrome c oxidase subunit	Two-component system	DB02949, DB03224	2-Acetyl-Protoporphyrin Ix, 2-Formyl-Protoporphryn Ix	Experimental (2)
32	Q0PBM2	cheA	Chemotaxis histidine kinase	Two-component system, Bacterial chemotaxis	DB02524, DB03909, DB04395	Spiro(2,4,6-Trinitrobenzene[1,2a]-2o',3o'-Methylene-Adenine-Triphosphate, Adenosine-5′-[Beta, Gamma-Methylene]Triphosphate, Phosphoaminophosphonic Acid-Adenylate Ester	Experimental (3)
33	Q0PBM1	cheV	Chemotaxis protein	Two-component system, Bacterial chemotaxis	DB02355, DB02596, DB07706, DB02461, DB03487, DB04156	Adenosine-5′-Rp-Alpha-Thio-Triphosphate, Alpha,Beta-Methyleneadenosine-5′-Triphosphate, 2,3,17beta-trihydroxy-1,3,5(10)-estratriene, S-Methyl Phosphocysteine, 3-Aminosuccinimide, Aspartate Beryllium Trifluoride	Experimental (6)
34	P0C635	cheY	Chemotaxis protein	Two-component system, Bacterial chemotaxis	DB02461, DB03487, DB04156,	S-Methyl Phosphocysteine, 3-Aminosuccinimide, Aspartate Beryllium Trifluoride,	Experimental (3)