Table 3.

Uni- and multivariate analyses adjusted by Framingham risk factors including age, sex, hypertension, diabetes mellitus, current smoking, and dyslipidaemia

	Univariate			Multivariate (CAD RF adjusted)
	HR	95% CI	P-value	HR	95% CI	P-value
Left dominant
None/normal	1	Reference	Reference	1	Reference	Reference
Non-obstructive	2.79	0.77–10.1	0.1172	1.67	0.34–8.27	0.5278
Obstructive (50–70%)	10.31	2.88–36.8	0.0003	9.75	2.10–45.2	0.0036
Severe obstructive (>70%)	20.67	6.81–62.8	<0.0001	18.16	4.19–78.8	0.0001
Right dominant
None/normal	1	Reference	Reference	1	Reference	Reference
Non-obstructive	4.78	3.01–7.59	<0.0001	3.39	2.06–5.59	<0.0001
Obstructive (50–70%)	23.38	14.9–36.7	<0.0001	15.08	9.12–24.9	<0.0001
Severe obstructive (>70%)	35.58	23.7–53.4	<0.0001	22.83	14.2–36.8	<0.0001

HRs of CAD (non-obstructive: <50% stenosis, obstructive: >50%stenosis, severe obstructive: >70%stenosis) for the composite outcome of all-cause mortality, non-fatal MI, and coronary revascularization in LCD and RCD compared with normal coronary arteries on CCTA. Patients with a balanced coronary artery system were excluded from the analysis.

CAD, coronary artery disease; RF, risk factor; HR, hazard ratio; CI, confidence interval.