Table 1. Demographic and peri-operative variables.
| Variable | levels | Overall | Low BOD (n = 60) | High BOD (n = 100) | p-value* |
|---|---|---|---|---|---|
| Age | Mean (sd) | 67.4 (12.7) | 67 (12.5) | 67.7 (12.9) | 0.619 |
| range | (29, 89) | (29, 89) | (34, 88) | ||
| Sex | F | 91 (56.9) | 42 (70.0) | 49 (49.0) | 0.013 |
| M | 69 (43.1) | 18 (30.0) | 51 (51.0) | ||
| Breslow depth (mm) | Mean (sd) | 3.4 (2.5) | 3.2 (2.7) | 3.5 (2.4) | 0.382 |
| Extremity | Upper | 32 (20.0) | 9 (15.0) | 23 (23.0) | 0.312 |
| Lower | 128 (80.0) | 51 (85.0) | 77 (77.0) | ||
| Clinical Site | Duke | 85 (53.1) | 34 (56.7) | 51 (51.0) | 0.539 |
| Moffitt | 75 (46.9) | 26 (43.3) | 49 (49.0) | ||
| Papaverine | No | 41 (25.6) | 16 (26.7) | 25 (25.0) | 0.846 |
| Yes | 119 (74.4) | 44 (73.3) | 75 (75.0) | ||
| Mean Blood Gas values from circuit after 30 minutes of circulation (SD) | Base Excess | -9.6 (3.8) | -9.8 (3.2) | -9.4 (4.2) | 0.529 |
| PaO2 | 10.1 (7.2) | 10 (7.9) | 10.2 (6.8) | 0.577 | |
| pH | 7.2 (0.1) | 7.2 (0.1) | 7.2 (0.1) | 0.759 | |
| Ischemia time (min) | Mean (sd) | 64.4 (16.5) | 64.2 (14.7) | 64.6 (17.5) | 0.879 |
| Post-op CPK peak values | Mean (sd) | 1577 (2640.3) | 2180 (3505.2) | 1218 (1883.5) | 0.068 |
| Wieberdink Peak Score | 1 | 20 (12.5) | 4 (6.7) | 16 (16.0) | 0.236 |
| 2 | 85 (53.1) | 34 (56.7) | 51 (51.0) | ||
| 3 | 43 (26.9) | 19 (31.7) | 24 (24.0) | ||
| 4 | 8 (5.0) | 2 (3.3) | 6 (6.0) | ||
| unavailable | 4 (2.5) | 1 (1.7) | 3 (3.0) |
*
Exact Chi-square test with monte carlo simulation BOD- Burden of Disease, CPK-Creatine Phosphokinase