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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Pain. 2015 Apr;156(0 1):S2–10. doi: 10.1097/01.j.pain.0000460345.92588.4b

Figure 2. Phosphatidylinositol (PI) synthetic pathways.

Figure 2

Phosphatidylinositol (PI) can be phosphorylated at the D3, D4 and D5 position of the inositol ring by PI3K, PI4K and PIKfyve respectively. The majority of all phosphatidylinositol 4,5-bisphosphate (PIP2) is synthesized via phosphorylation of PI(4)P by PIP5KIs. PIP2 can undergo further phosphorylation by class I PI3Ks to generate PIP3. R2 and R1 are the fatty acid chains that make up diacylglycerol (DAG). Phosphate groups are red. Figure based on reactions catalyzed in vivo [70]. Image adapted from [75]. Gene names for respective kinases are shown in parentheses.