Table 3.
Physiological changes associated with liver cirrhosis (fractions of healthy control values ± standard deviation)a
| Child–Pugh Grade | ||||
|---|---|---|---|---|
| Parameter | A | B | C | |
| Albumin concentration | 0.84±0.15 | 0.69±0.15 | 0.53±0.15 | |
| Hematocrit (%)b | 38±5.0 | 34±5.7 | 34±5.5 | |
| Cardiac output | 1.1±0.39 | 1.2±0.34 | 1.3±0.30 | |
| Portal vein blood flow | 0.72±0.57 | 0.60±0.61 | 0.13±0.57 | |
| Splenic vein blood flow | 1.2±0.29 | 1.5±0.52 | 1.5±0.54 | |
| Liver arterial blood flow | 1.5±1.1 | 1.7±1.5 | 2.1±1.9 | |
| Functional liver size | 0.91±0.26 | 0.81±0.26 | 0.64±0.22 | |
| Liver transporter mRNA levelc | OATP1B1 | 0.65±0.49 | (0.65±0.49) | (0.65±0.49) |
| OATP1B3 | 0.73±0.59 | (0.73±0.59) | (0.73±0.59) | |
| OATP2B1 | 0.77±0.47 | (0.77±0.47) | (0.77±0.47) | |
| MRP2 | 0.54±0.48 | (0.54±0.48) | (0.54±0.48) | |
| BCRP | 0.58±0.45 | (0.58±0.45) | (0.58±0.45) | |
| BSEP | 1.1±0.51 | (1.1±0.51) | (1.1±0.51) | |
| MDR1 | 1.1±0.49 | (1.1±0.49) | (1.1±0.49) | |
| MDR3 | 2.3±0.45 | (2.3±0.45) | (2.3±0.45) | |
| MATE1 | 0.65±0.52 | (0.65±0.52) | (0.65±0.52) | |
| Uptake transporter activityd | 0.78±0.070 | 0.31±0.033 | (0.31±0.033) | |
| Efflux transporter activityd | 0.69±0.12 | 2.6±17 | (2.6±17) | |
The individual values reported in each study and references are given in the supplementary materials.
Hematocrit is given as the volume percentage (%) of red blood cells in blood for CP-A, CP-B, and CP-C groups, rather than the fraction of control value. The hematocrit of healthy individuals is (42±3.3) %.
The reported liver transporter expression level data are not classified into Child–Pugh grade system, as such we assume that CP-A, CP-B, and CP-C groups share the same values. OATP1B1, 1B3, and 2B1 are uptake transporters, and others are biliary efflux transporters.
These values are determined by fitting observed clinical data. Standard deviations are approximated by residual bootstrap. We assume that CP-C group has the same values as CP-B group as mentioned in the text.